{"id":228465,"date":"2024-09-12T07:23:52","date_gmt":"2024-09-12T05:23:52","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/head-defect"},"modified":"2024-09-12T07:23:52","modified_gmt":"2024-09-12T05:23:52","slug":"head-defect","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/erbkrankheiten-katze\/head-defect\/","title":{"rendered":"Head Defect"},"content":{"rendered":"

Head Defect<\/h1>

General description<\/strong><\/h4>

The mutation causing the Burmese Head Defect affects function of a gene significant for facial development. One copy of the mutation does not cause the craniofacial defect but may produce a shortened facial structure (brachycephaly). Cats with two copies of the mutation have the severe craniofacial defect that is incompatible with life<\/p>

Breeds<\/span><\/strong><\/h4>

Burmese<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8465<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>skeletal<\/td><\/tr>
Inheritance<\/strong><\/td>see Infotext<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>ALX1<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001551-9685<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

The Burmese Head Defect is a congenital malformation of the head and face<\/strong> (craniofacial) that is widespread in modern Burmese cat lines. The causal genetic variant was discovered by the Lyons Feline Genetics Research Laboratory at UC Davis and affects a gene that plays an important role in facial development.<\/p>

One copy of the variant (heterozygous)<\/strong> does not cause malformation but is often responsible for a shortened facial skull<\/strong> (brachycephaly). Cats that inherit the variant from both parents (homozygous)<\/strong> have severe malformations<\/strong> and are not viable<\/strong>.<\/p><\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6265,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-228465","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/228465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/comments?post=228465"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/228465\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/6265"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media?parent=228465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}