{"id":218492,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/protein-losing-nephropathie-pln"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"protein-losing-nephropathie-pln","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/erbkrankheiten-hund\/protein-losing-nephropathie-pln\/","title":{"rendered":"Protein losing Nephropathie (PLN)"},"content":{"rendered":"

Protein losing nephropathy (PLN)<\/h1>

General description<\/strong><\/h4>

The Risk assessment for PLN is possible due to genetic testing. Hereditary PLN starts often with a hidden proteinuria in midlife. The disease can proceed mildly and stay steady for years. In some cases severe complications like kidney failure or thromboses occur. Nevertheless symptoms vary hugely and are supposed to depend on enviromental factors and modifying genes. <\/p>

Breeds<\/span><\/strong><\/h4>

Airedale Terrier, Irish Soft Coated Wheaten Terrier<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8492<\/td><\/tr>
Abbreviation<\/strong><\/td>PLN<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>nephrological<\/td><\/tr>
Age of onset<\/strong><\/td>middle age <\/td><\/tr>
Causality<\/strong><\/td>risk marker<\/td><\/tr>
Gene<\/strong><\/td>KIRREL2, NPHS1<\/td><\/tr>
Mutation<\/strong><\/td>G-C, G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001326-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Hereditary PLN starts with a hidden proteinuria in midlife. The disease can proceed mildly and stay steady for years. In some cases severe complications like kidney failure or thromboses occur. Risk assessment for PLN is possible due to genetic testing, now. Nevertheless, starting point and development of symptoms vary hugely and are supposed to depend on enviromental factors and modifying genes. Additionally, aquired forms of PLN disease can not be detected by the genetic test.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218492","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/218492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/comments?post=218492"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/218492\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fr\/wp-json\/wp\/v2\/media?parent=218492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}