{"id":218233,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/von-willebrand-erkrankung-typ-3-vwd-3"},"modified":"2025-07-22T11:49:46","modified_gmt":"2025-07-22T09:49:46","slug":"von-willebrand-erkrankung-typ-3-vwd-3","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/erbkrankheiten-hund\/von-willebrand-erkrankung-typ-3-vwd-3\/","title":{"rendered":"von-Willebrand Erkrankung Typ III (vWD3)"},"content":{"rendered":"

von-Willebrand disease type III (vWD3)<\/h1>

General description<\/strong><\/h4>

Von Willebrand disease (vWD) is a bleeding disorder caused by a quantitative or qualitative deficiency of von Willebrand factor (vWF) Symptoms of vWD are highly heterogeneous from mild bleeding to severe life-threatening blood loss and may be aggravated by mental or physical stress. The clinical expression of canine vWD type 3 is generally severe.<\/p>

Breeds<\/span><\/strong><\/h4>

Havanese, Kooikerhondje, Scottish Terrier, Shetland Sheepdog (Sheltie) <\/p>

Detailed description<\/summary>

The most common form of canine hereditary bleeding disorders<\/strong> is the von Willebrand disease (vWD). The condition is caused by a quantitative or qualitative deficiency of von Willebrand factor (vWF), which is an essential component of the blood coagulation cascade. A defect of the vWF leads to uncontrolled bleeding upon inquiries or spontaneous<\/strong>. Clinical symptoms of vWD are highly heterogeneous from mild bleeding to severe life-threatening blood loss and may be aggravated by mental or physical stress.<\/p>

Typical signs are: repeated gastrointestinal bleeding<\/strong> with or without diarrhea, epistaxis, bleeding after dental extraction, gingival bleeding, ecchymosis, extended bleeding during heat, lameness due to bleeding inside the joints, excessive bleeding upon nail cutting or docking or postoperative<\/strong>.<\/p>

VWD is divided into three major categories: type 1, type 2 and type 3 as well as diverse subtypes. Type 3 of vWD displays the most severe vWD form<\/strong>. Classical symptoms are a high tendency to severe bleeding after injury, surgery or to spontaneous bleeding. In the past this variant was thought to be uncommon in dogs. However, a relatively high prevalence has been detected in Scottish Terriers and Shetland Sheepdogs.<\/p>

The inheritance and expression of type 3 vWD is autosomal recessive<\/strong> wherein affected (homozygous) dogs lack vWF protein, and carrier (heterozygous) dogs have low plasma vWF protein concentration but are clinically normal.<\/p><\/p><\/details><\/div><\/div>

<\/div><\/div>

vWD type III - Havanese<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8233<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Gene<\/strong><\/td>VWF<\/td><\/tr>
Mutation<\/strong><\/td>A-C<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001058-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

vWD type III - Kooikerhondje<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8233<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>VWF<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001058-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

vWD type III - Scottish Terrier<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8233<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>VWF<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001058-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

vWD type III - Shetland Sheepdog (Sheltie) <\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8233<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>VWF<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001058-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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