{"id":218068,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/muskeldystrophie-md"},"modified":"2025-07-22T10:56:16","modified_gmt":"2025-07-22T08:56:16","slug":"muskeldystrophie-md","status":"publish","type":"page","link":"https:\/\/labogen.com\/fr\/erbkrankheiten-hund\/muskeldystrophie-md\/","title":{"rendered":"Muskeldystrophie (MD) – American Staffordshire Terrier, Cavalier King Charles Spaniel, Golden Retriever, Landseer, Norfolk Terrier"},"content":{"rendered":"

Muscular dystrophy (MD)<\/h1>

General description<\/strong><\/h4>

Dogs affected by Muscular Dystrophy show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. Syptoms might show as whole-body muscular weakness and clumsy motion. In the breed American Staffordshire Terrier, a variant of the COL6A3 gene has been identified to cause congenital muscular dystrophy. First symptoms like progressive gait abnormalities and joint contracture become obvious at the age of 6 months. <\/p>

Breeds<\/span><\/strong><\/h4>

American Staffordshire Terrier, Cavalier King Charles Spaniel, Cavapoo, Golden Retriever, Goldendoodle, Landseer, Norfolk Terrier<\/p>

Detailed description<\/summary>

Muscular dystrophy (MD) is a slowly progressive, hereditary muscular atrophy. <\/p><\/details><\/div><\/div>

<\/div><\/div>

Muscular Dystrophy - Cavalier King Charles Spaniel<\/h4>

Muscular dystrophy in Cavalier King Charles Spaniel, Golden Retriever and Norfolk Terrier is a spontaneous, X-linked, progressively fatal disease of dogs. Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8068<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>X-chromosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>DMD<\/td><\/tr>
Mutation<\/strong><\/td>C-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001081-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Muscular Dystrophy - Golden Retriever<\/h4>

Muscular dystrophy in Cavalier King Charles Spaniel, Golden Retriever and Norfolk Terrier is a spontaneous, X-linked, progressively fatal disease of dogs. Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8068<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>X-chromosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>DMD<\/td><\/tr>
Mutation<\/strong><\/td>T-C<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001081-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Muscular Dystrophy - Norfolk Terrier<\/h4>

Muscular dystrophy in Cavalier King Charles Spaniel, Golden Retriever and Norfolk Terrier is a spontaneous, X-linked, progressively fatal disease of dogs. Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. <\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8068<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>X-chromosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>DMD<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001081-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Muscular Dystrophy - American Staffordshire Terrier<\/h4>

In the breed American Staffordshire Terrier, a variant of the COL6A3 gene has been identified to cause congenital muscular dystrophy. First symptoms like progressive gait abnormalities and joint contracture become obvious at the age of 6 months. Affected dogs show diffuse muscle atrophy and multifocal joint contracture with reduced range of motion and marked thickening of the elbow and stifle joints, along with distal limb joint hyperlaxity. Additional symptoms are severe generalized weakness, such that they had difficulty rising and ambulating, as well as ambulatory tetraparesis with a stiff, choppy, short-strided gait in all limbs without obvious ataxia. Weak withdrawal reflexes were seen in all limbs.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8068<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6 months<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>COL6A3<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002274-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Muscular Dystrophy - Landseer<\/h4>

Landseer muscular dystrophy is inherited as an autosomal recessive trait. Affected dogs exhibit a general, whole body muscular weakness, they move slowly and clumsy and some cannot walk at all. First symptoms in the course of movement appear at the age of three to six month. Affected dogs usually die between the ages of 4 and 24 months.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8068<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>3-5 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>3-6 months<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>COL6A1<\/td><\/tr>
Mutation<\/strong><\/td>G-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001967-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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