{"id":270305,"date":"2024-03-13T18:07:01","date_gmt":"2024-03-13T17:07:01","guid":{"rendered":"https:\/\/staging.laboklin.com\/labogen\/labogen_wp\/index.php\/2024\/03\/13\/genetic-test-for-pra-with-neurodegeneration-pcyt2-deficiency-in-the-saarloos-wolfhound\/"},"modified":"2024-09-24T15:52:25","modified_gmt":"2024-09-24T13:52:25","slug":"genetic-test-for-pra-with-neurodegeneration-pcyt2-deficiency-in-the-saarloos-wolfhound","status":"publish","type":"post","link":"https:\/\/labogen.com\/fi\/2024\/03\/13\/genetic-test-for-pra-with-neurodegeneration-pcyt2-deficiency-in-the-saarloos-wolfhound\/","title":{"rendered":"Genetic test for PRA with Neurodegeneration (PCYT2 deficiency) in the Saarloos Wolfdog"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"270305\" class=\"elementor elementor-270305 elementor-7045\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a680706 e-flex e-con-boxed e-con e-parent\" data-id=\"a680706\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f64646a elementor-widget elementor-widget-text-editor\" data-id=\"5f64646a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2>Genetic test for PRA with Neurodegeneration (PCYT2 deficiency) in the Saarloos Wolfdog<\/h2>\n<div class=\"x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a\">\n<p>A genetic variant of the PCYT2 gene in Saarloos wolfdogs can be associated with a disease that leads to both blindness and neurodegeneration.<\/p>\n<p>Affected dogs suffer from retinal degeneration, which begins in early adulthood. The typical ophthalmological changes of generalized progressive retinal atrophy (PRA) occur, while the first clinical signs become visible between 20 and 46 months of age. In addition, the affected dogs show neurological deficits from later adulthood, such as gait abnormalities, weakness of the hind limbs, tremor, ataxia, decline in cognitive abilities and behavioral problems, especially aggression towards the owner. Epileptic seizures have also been reported in some dogs.<\/p>\n<p>Unfortunately, the affected dogs often have to be euthanised due to the progressive neurological signs and the resulting impairment of their quality of life.<\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b5e81a0 e-flex e-con-boxed e-con e-parent\" data-id=\"b5e81a0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2ebc7fe e-con-full e-flex e-con e-child\" data-id=\"2ebc7fe\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a76e6c7 elementor-align-center elementor-widget elementor-widget-ibutton\" data-id=\"a76e6c7\" data-element_type=\"widget\" data-widget_type=\"ibutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ot-button\">\r\n\t\t\t<a href=\"https:\/\/labogen.com\/en\/hereditary-diseases\/\" class=\"octf-btn octf-btn-dark\">Further information can be found here<\/a>\r\n\t    <\/div>\r\n\t    \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e54858 e-con-full e-flex e-con e-child\" data-id=\"4e54858\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d43454 elementor-align-center elementor-widget elementor-widget-ibutton\" data-id=\"4d43454\" data-element_type=\"widget\" data-widget_type=\"ibutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ot-button\">\r\n\t\t\t<a href=\"https:\/\/shop.labogen.com\/en\/\" class=\"octf-btn octf-btn-dark\">Order now<\/a>\r\n\t    <\/div>\r\n\t    \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A genetic variant of the PCYT2 gene in Saarloos wolfdogs can be associated with a disease&#8230;<\/p>\n","protected":false},"author":5,"featured_media":9186,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146],"tags":[149,148],"class_list":["post-270305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hund-fi","tag-gentest-fi","tag-hund-fi"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/posts\/270305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/comments?post=270305"}],"version-history":[{"count":2,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/posts\/270305\/revisions"}],"predecessor-version":[{"id":272100,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/posts\/270305\/revisions\/272100"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media\/9186"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media?parent=270305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/categories?post=270305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/tags?post=270305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}