{"id":228113,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/glycogenspeicherkrankheit-typ-iv-gsd4"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"glycogenspeicherkrankheit-typ-iv-gsd4","status":"publish","type":"page","link":"https:\/\/labogen.com\/fi\/erbkrankheiten-katze\/glycogenspeicherkrankheit-typ-iv-gsd4\/","title":{"rendered":"Glycogenspeicherkrankheit Typ IV (GSD4)"},"content":{"rendered":"

Glycogen storage disease type IV (GSD4)<\/h1>

General description<\/strong><\/h4>

Glycogen storage disease type IV (GSD IV) is an inherited abnormality of glucose metabolism. Deficiency of GBE activity leads to abnormal glycogen accumulation in myocytes, hepatocytes, and neurones, causing variably progressive, benign to lethal organ dysfunctions. Most affected kittens die at or soon after birth, presumably due to hypoglycemia.<\/p>

Breeds<\/span><\/strong><\/h4>

Norwegian Forest Cat<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8113<\/td><\/tr>
Abbreviation<\/strong><\/td>GSD4<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>neuromuscular<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>5 months<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>GBE1<\/td><\/tr>
Mutation<\/strong><\/td>COMPLEX<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000420-9685<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Glycogen storage disease type IV (GSD IV) of the Norwegian forest cat is an inherited abnormality of glucose metabolism. Normally, excess glucose is stored in many tissues as glycogen. If energy is needed, glucose molecules are removed from glycogen. The ability to add and remove glucose molecules from glycogen efficiently is dependent on its highly branched structure. The glycogen branching enzyme (GBE) is an enzyme of glycogen synthesis necessary to produce the branching structure. Deficiency of GBE activity leads to abnormal glycogen accumulation in myocytes, hepatocytes, and neurones, causing variably progressive, benign to lethal organ dysfunctions. Most affected kittens die at or soon after birth, presumably due to hypoglycemia. Survivors of the perinatal period appear clinically normal until onset of progressive neuromuscular degeneration at 5 month of age. <\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6265,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-228113","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/228113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/comments?post=228113"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/228113\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/6265"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media?parent=228113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}