{"id":218688,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/exfoliativer-kutaner-lupus-erythematodes-ecle"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"exfoliativer-kutaner-lupus-erythematodes-ecle","status":"publish","type":"page","link":"https:\/\/labogen.com\/fi\/erbkrankheiten-hund\/exfoliativer-kutaner-lupus-erythematodes-ecle\/","title":{"rendered":"Exfoliativer kutaner Lupus erythematodes (ECLE)"},"content":{"rendered":"

Exfoliative cutaneous lupus erythematosus (ECLE)<\/h1>

General description<\/strong><\/h4>

Typical symptoms are excessive skin scales, first at the face and later also at the ears, the back and the whole body. Moreover, loss of pigmentation of the skin (hypopigmentation) as well as erythemas can occur. As the disease progresses, hair loss, crusts, ulcers and temporary lameness are possible symptoms. The onset of the disease is usally at an juvenile or early adult age.<\/p>

Breeds<\/span><\/strong><\/h4>

German Short-haired Pointing Dog, Hungarian Vizsla<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8688<\/td><\/tr>
Abbreviation<\/strong><\/td>ECLE<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>dermatologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>UNC93B1<\/td><\/tr>
Mutation<\/strong><\/td>C-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001609-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Exfoliative cutaneous lupus erythematosus (ECLE) is an autoimmune skin disease<\/strong>. The underlying cause of this disease at the breeds German Shorthaired Pointer and Magyar Vizsla<\/strong> is a variant of the UNC93B1<\/em> gene<\/strong>, which plays an important role for the innate immune system and therefore the immune resonse against pathogens<\/strong>.<\/p>

Typical symptoms are excessive skin scales<\/strong>, first at the face and later also at the ears, the back and the whole body. Moreover, loss of pigmentation of the skin<\/strong> (hypopigmentation) as well as erythemas<\/strong> can occur. As the disease progresses, hair loss, crusts, ulcers and temporary lameness<\/strong> are possible symptoms.<\/p>

The onset of the disease is usally at an juvenile or early adult age<\/strong>. Due to the severe symptoms, affected dogs usually have to be euthanized.<\/p> <\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218688","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/comments?post=218688"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218688\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media?parent=218688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}