{"id":218612,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/entzuendliche-myopathie-im"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"entzuendliche-myopathie-im","status":"publish","type":"page","link":"https:\/\/labogen.com\/fi\/erbkrankheiten-hund\/entzuendliche-myopathie-im\/","title":{"rendered":"Entz\u00fcndliche Myopathie (IM)"},"content":{"rendered":"

Inflammatory myopathy (IM)<\/h1>

General description<\/strong><\/h4>

Five related Dutch Shepherd dogs have been found to suffer from an inflammatory myopathy with generalized muscle weakness and severe muscle atrophy. Typical symptoms are muscle tremors, stiff short-strided gait and weakness progressing to inability to walk, beginning at 3 to 9 months of age. <\/p>

Breeds<\/span><\/strong><\/h4>

Dutch Shepherd Dog<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8612<\/td><\/tr>
Abbreviation<\/strong><\/td>IM<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>muscular<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>3-9 months<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>SLC25A12<\/td><\/tr>
Mutation<\/strong><\/td>A-G<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002294-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Inflammatory myopathies<\/strong> are a large group of disorders characterized by infiltration of inflammatory cells into muscle<\/strong>.<\/p>

Five related Dutch Shepherd dogs have been found to suffer from an inflammatory myopathy with generalized muscle weakness and severe muscle atrophy<\/strong>. Due to the early onset of the symptoms and the presence of related affected dogs, a genetic cause was suspected. A genetic variant in the SLC25A12<\/em> gene<\/strong>, which encodes for a mitochondrial aspartate-glutamate transporter (AGC1), has been found to correlate with the symptoms of the disease. Due to the variant, the transporter shows a decreased transport activity and therefore a proinflammatory milieu and oxidative stress in muscles. <\/p>

Typical symptoms are muscle tremors, stiff short-strided gait and weakness progressing to inability to walk<\/strong>, beginning at 3 to 9 months of age<\/strong>. Serum CK activities (a marker of muscle damage) is persistently elevated at affected dog. Dogs were euthanized by 2 years of age because of the progression of weakness. <\/p>

The described variant has neither been found in Dutch Shepherd related breeds, like Belgian Shepherds or German Shepherds, nor in other unrelated breeds other than the Dutch Shepherd, so far. <\/p> <\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218612","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/comments?post=218612"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218612\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media?parent=218612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}