{"id":218434,"date":"2024-09-12T07:23:50","date_gmt":"2024-09-12T05:23:50","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/congenitale-hypothyreose-chg"},"modified":"2024-09-12T07:23:50","modified_gmt":"2024-09-12T05:23:50","slug":"congenitale-hypothyreose-chg","status":"publish","type":"page","link":"https:\/\/labogen.com\/fi\/erbkrankheiten-hund\/congenitale-hypothyreose-chg\/","title":{"rendered":"Congenitale Hypothyreose (CHG)"},"content":{"rendered":"

Congenital hypothyroidism with goiter (CHG)<\/h1>

General description<\/strong><\/h4>

In affected pups a delay in growth occurs, which becomes obvious at about two weeks of age comparing with healthy pups. Opening of the eyes and ear canals is delayed and the thyroid glands are enlarged (goiter). Bones do not lenghten appropriately causing irreversible dwarfism. <\/p>

Breeds<\/span><\/strong><\/h4>

Fox Terrier, French Bulldog, Rat Terrier, Spanish Water Dog, Tenterfield Terrier, Toy Fox Terrier<\/p>

Detailed description<\/summary>

The term hypothyroidism stands for all types of thyroid gland hypofunctions, regardeless of the cause of the disease. The disease manifests itself in delayed growth<\/strong> in puppies, which becomes obvious at the age of 2 weeks<\/strong>. While healthy puppies experience a growth spurt at this stage, the development of affected dogs stops. Sudden deaths during this period have also been reported. The opening of the eyes and ear canals is significantly delayed<\/strong> by this disorder. Insufficient thyroid hormone levels in the blood of affected dogs impact bone growth (dwarfism)<\/strong> and cause the thyroid gland (thyroidea) to enlarge<\/strong> as a compensatory response. This can lead to palpable thick nodules in the neck and nape region.<\/p>

If the disease is diagnosed in time, daily lifelong doses of thyroid hormones can reduce the severity, although dwarfism is an irreversible consequence. Otherwise, affected dogs have a rather low life expectancy and usually die as puppies.<\/p><\/p><\/details><\/div><\/div>

<\/div><\/div>

Congenital Hypothyroidism with goiter (CHG) - Fox, Rat Terrier<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8434<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>2 weeks <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>TPO<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000536-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Congenital Hypothyroidism with goiter (CHG) - French Bulldog<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8434<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>2 weeks <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>TPO<\/td><\/tr>
Mutation<\/strong><\/td>T-C<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000536-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Congenital Hypothyroidism with goiter (CHG) - Spanish Water Dog<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8434<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>2 weeks <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>TPO<\/td><\/tr>
Mutation<\/strong><\/td>INS<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000536-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Congenital Hypothyroidism with goiter (CHG) - Tenterfield Terrier<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8434<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>systemic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>2 weeks <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>TPO<\/td><\/tr>
Mutation<\/strong><\/td>C-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000536-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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