{"id":218141,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/praekallikrein-defizienz-klk"},"modified":"2024-09-12T07:23:48","modified_gmt":"2024-09-12T05:23:48","slug":"praekallikrein-defizienz-klk","status":"publish","type":"page","link":"https:\/\/labogen.com\/fi\/erbkrankheiten-hund\/praekallikrein-defizienz-klk\/","title":{"rendered":"Pr\u00e4kallikrein Defizienz (KLK)"},"content":{"rendered":"

Prekallikrein deficiency (KLK)<\/h1>

General description<\/strong><\/h4>

Prekallikrein deficiency (KLK) is a bleeding disorder. The causative mutation is rarely found and affected dogs did show neurological symptoms as well.<\/p>

Breeds<\/span><\/strong><\/h4>

Shih Tzu<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8141<\/td><\/tr>
Abbreviation<\/strong><\/td>KLK<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>KLKB1<\/td><\/tr>
Mutation<\/strong><\/td>A-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:000819-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Prekallikrein deficiency (KLK) leads to loss of prekallikrein function, a member of the coagulation cascade. Affected dogs show no to little symptoms of prolonged bleeding. In combination with other defects in the coagulation cascade (factor VII, VIII and IX deficiency) Prekallikrein deficiency affected dogs did exhibit stronger bleeding.<\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218141","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/comments?post=218141"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/218141\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/fi\/wp-json\/wp\/v2\/media?parent=218141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}