{"id":286479,"date":"2025-12-10T14:25:52","date_gmt":"2025-12-10T13:25:52","guid":{"rendered":"https:\/\/labogen.com\/2025\/12\/10\/glycogen-storage-disease-gsd-pgbm1-in-the-basset-hound\/"},"modified":"2026-02-19T11:50:42","modified_gmt":"2026-02-19T10:50:42","slug":"glycogen-storage-disease-gsd-pgbm1-in-the-basset-hound","status":"publish","type":"post","link":"https:\/\/labogen.com\/en\/2025\/12\/10\/glycogen-storage-disease-gsd-pgbm1-in-the-basset-hound\/","title":{"rendered":"Glycogen storage disease (GSD-PGBM1) in the Basset Hound"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"286479\" class=\"elementor elementor-286479 elementor-285538\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b384304 e-flex e-con-boxed e-con e-parent\" data-id=\"b384304\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-55f4cb2 elementor-widget elementor-widget-text-editor\" data-id=\"55f4cb2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2>Glycogen storage disease (GSD-PGBM1) in the Basset Hound<\/h2><div class=\"x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a\"><p>Glycogen storage diseases (GSDs) are hereditary <strong>metabolic disorders<\/strong> in which too much glycogen is stored in various tissues due to faulty enzymes. A <strong>genetic variant <\/strong>in the<strong> <em>RBCK1 gene<\/em><\/strong> was discovered in the Basset Hound, which leads to the formation of so-called polyglucosan storage bodies and can cause serious health problems. Affected dogs often initially show <strong>chronic vomiting<\/strong> and <strong>diarrhea<\/strong>, usually from around <strong>8 to 12 months of<\/strong> age. Later on, progressive <strong>muscle weakness<\/strong>, <strong>exercise intolerance<\/strong> and serious <strong>heart problems<\/strong> with heart failure and even sudden cardiac death can occur.<\/p><p>As the disease progresses gradually and often causes only minimal changes in blood values at the beginning, genetic testing can provide valuable information for the diagnosis. In addition, carrier animals can be identified at an early stage using the genetic test, which is of great importance for responsible breeding planning.<\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-67d4591 e-flex e-con-boxed e-con e-parent\" data-id=\"67d4591\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7f37294 e-con-full e-flex e-con e-child\" data-id=\"7f37294\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4a9daca elementor-align-center elementor-widget elementor-widget-ibutton\" data-id=\"4a9daca\" data-element_type=\"widget\" data-widget_type=\"ibutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ot-button\">\r\n\t\t\t<a href=\"https:\/\/labogen.com\/en\/genetic-diseases-dog\/gylcogen-storage-disease-gsd-pgbm1\/\" class=\"octf-btn octf-btn-dark\">Further information can be found here<\/a>\r\n\t    <\/div>\r\n\t    \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f620c18 e-con-full e-flex e-con e-child\" data-id=\"f620c18\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06d4b57 elementor-align-center elementor-widget elementor-widget-ibutton\" data-id=\"06d4b57\" data-element_type=\"widget\" data-widget_type=\"ibutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ot-button\">\r\n\t\t\t<a href=\"https:\/\/shop.labogen.com\/en\/\" class=\"octf-btn octf-btn-dark\">Order now<\/a>\r\n\t    <\/div>\r\n\t    \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Glycogen storage disease (GSD-PGBM1) in the Basset Hound Glycogen storage diseases (GSDs) are hereditary metabolic disorders in which too much glycogen is stored in various tissues due to faulty enzymes. A genetic variant in the RBCK1 gene was discovered in the Basset Hound, which leads to the formation of so-called polyglucosan storage bodies and can [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":286478,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[128],"tags":[131,130],"class_list":["post-286479","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dog","tag-dog","tag-genetic-test"],"_links":{"self":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/posts\/286479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/comments?post=286479"}],"version-history":[{"count":1,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/posts\/286479\/revisions"}],"predecessor-version":[{"id":286480,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/posts\/286479\/revisions\/286480"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/media\/286478"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/media?parent=286479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/categories?post=286479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/tags?post=286479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}