{"id":268548,"date":"2024-09-12T07:24:01","date_gmt":"2024-09-12T05:24:01","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/dwarfism-acan-chrondrodysplasie"},"modified":"2024-09-12T07:24:01","modified_gmt":"2024-09-12T05:24:01","slug":"dwarfism-acan-chrondrodysplasie","status":"publish","type":"page","link":"https:\/\/labogen.com\/en\/genetic-diseases-horse\/dwarfism-acan-chrondrodysplasie\/","title":{"rendered":"Dwarfism (ACAN, Chrondrodysplasie)"},"content":{"rendered":"

Dwarfism (ACAN, Chrondrodysplasie)<\/h1>

General description<\/strong><\/h4>

Dwarfism is most common in Shetland ponies and miniature horses. Phenotypical features of this hereditary disease are breathing problems due to a cleft palate, deformed mouths, shortened limbs and bowed forelegs, disproportionately large cranium and shortened neck, protruding eyes, abdominal hernia and a shortened rib cage.<\/p>

Breeds<\/span><\/strong><\/h4>

American Miniature Horse, Shetland pony<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8548<\/td><\/tr>
Abbreviation<\/strong><\/td>ACAN<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, mane\/tail hair roots<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>skeletal<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001271-9796<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Dwarfism is most common in Shetland ponies and miniature horses. Phenotypical features of this hereditary disease are breathing problems due to a cleft palate, deformed mouths, shortened limbs and bowed forelegs, disproportionately large cranium and shortened neck, protruding eyes, abdominal hernia and a shortened rib cage. As a result, affected animals are often not viable or have to be euthanized due to the poor quality of life. A mutation in the ACAN gene is responsible for this form of dwarfism. 4 different mutations, which cause the autosomal-recessive disease, are known so far. These are named D1, D2, D3*, and D4 and are also pathogenic as compound heterozygous genes. Compound heterozygous variants together with D1 (except N\/D1) are more deleterious and often lead to death. A combination with the D2 variant is considered as the mildest form of dwarfism. <\/p><\/details><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":8789,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-268548","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/268548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/comments?post=268548"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/268548\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/8789"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/media?parent=268548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}