{"id":218737,"date":"2024-09-12T07:23:51","date_gmt":"2024-09-12T05:23:51","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/afibrinogenaemie-afg"},"modified":"2024-09-12T07:23:51","modified_gmt":"2024-09-12T05:23:51","slug":"afibrinogenaemie-afg","status":"publish","type":"page","link":"https:\/\/labogen.com\/en\/erbkrankheiten-hund\/afibrinogenaemie-afg\/","title":{"rendered":"Afibrinogen\u00e4mie (AFG)"},"content":{"rendered":"

Afibrinogenemia (AFG)*<\/h1>

General description<\/strong><\/h4>

Typical signs of bleeding disorders are prolonged clotting time, cord or mucosal bleeding and haematomas. They can lead to uncontrolled severe bleeding upon surgeries, injuries or spontaneous. In Dachshunds, a genetic variant of the FGA (fibrinogen alpha chain) gene has been found to be associated with afibrinogenemia, leading to a severe form of bleeding tendency.<\/p>

Breeds<\/span><\/strong><\/h4>

Dachshund (Dackel), Long-Haired Dachshund, Short-Haired Dachshund, Wire-Haired Dachshund<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8737<\/td><\/tr>
Abbreviation<\/strong><\/td>AFG<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>hematologic<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>FGA<\/td><\/tr>
Mutation<\/strong><\/td>DEL<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002382-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
Detailed description<\/summary>

Typical signs of bleeding disorders are prolonged clotting time, cord or mucosal bleeding and haematomas. They can lead to uncontrolled severe bleeding upon surgeries, injuries or spontaneous. <\/p>

In Dachshunds, a genetic variant of the FGA<\/em> (fibrinogen alpha chain) gene has been found to be associated with afibrinogenemia, leading to a severe form of bleeding tendency. Afibrinogenemia is characterized by the absence of coagulation factor I (fibrinogen), a glycoprotein with a central role in the final step of coagulation cascade in hemostasis. <\/p>

Affected dogs show extremely prolonged clotting times at different coagulation tests (PT, aPTT, TT), normal activities of factors II, V, VII and X, and normal platelet counts. <\/p><\/p><\/details><\/div>

* Service is done by partner lab<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":6261,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-218737","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/218737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/comments?post=218737"}],"version-history":[{"count":0,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/218737\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/pages\/6261"}],"wp:attachment":[{"href":"https:\/\/labogen.com\/en\/wp-json\/wp\/v2\/media?parent=218737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}