{"id":218192,"date":"2024-09-12T07:23:48","date_gmt":"2024-09-12T05:23:48","guid":{"rendered":"http:\/\/staging.laboklin.com\/labogen\/labogen_wp\/familiaere-nephropathie-fn"},"modified":"2025-07-17T09:42:58","modified_gmt":"2025-07-17T07:42:58","slug":"familiaere-nephropathie-fn","status":"publish","type":"page","link":"https:\/\/labogen.com\/en\/erbkrankheiten-hund\/familiaere-nephropathie-fn\/","title":{"rendered":"Famili\u00e4re Nephropathie (FN) – English Springer Spaniel, Samojede"},"content":{"rendered":"

Familial nephropathy (FN)<\/h1>

General description<\/strong><\/h4>

The Familial or Hereditary Nephropathy (FN) is a juvenile-onset fatal kidney disease. The renal disease caused by FN invariably is progressive and ultimately fatal. Dogs with FN typically develop chronic renal failure between 6 month and 2 years of age, with eventual and sometimes rapid destruction of both kidneys. The first clinical signs are excessive water consumption, growth rate or loss in weight, reduced appetite, and vomiting.<\/p>

Breeds<\/span><\/strong><\/h4>

English Springer Spaniel, Samoyed<\/p>

Detailed description<\/summary>

The main functions of the kidneys are to excrete water, foreign substances, electrolytes and metabolic waste products. The glomeruli of the kidney act as a filter, separating urine from blood and thus filtering out the primary urine. A network of Type IV collagen fibres are essential for the correct structure of the glomerular basement membrane and thus for kidney function.<\/p>

The progressive kidney disease caused by familial or hereditary nephropathy (FN)<\/strong> is caused by a <\/strong>type IV collagen defect<\/strong>. Dogs with FN develop chronic renal dysfunction<\/strong> between the ages of 6 months and 2 years<\/strong>, which eventually, in some cases very rapidly, leads to destruction of both kidneys and death<\/strong>. Initial clinical signs include excessive thirst, reduced growth rate or weight loss, reduced appetite and vomiting<\/strong>.<\/p> <\/p><\/details><\/div><\/div>

<\/div><\/div>

Familial Nephropathy (FN) - English Springer Spaniel<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8192<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>nephrological<\/td><\/tr>
Inheritance<\/strong><\/td>autosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6 months- 2 years <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>COL4A4<\/td><\/tr>
Mutation<\/strong><\/td>G-A<\/td><\/tr>
Literature<\/strong><\/td>OMIA:002618-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>

Familial Nephropathy (FN) - Samoyed<\/h4>

The symptoms described in this breed can be found in the text above.<\/p><\/div>

Order details<\/summary>
Test number<\/strong><\/span><\/td>8192<\/td><\/tr>
Sample material<\/strong><\/td>0.5 ml EDTA blood, 2x cheek swab, 1x special swab (eNAT)<\/td><\/tr>
Test duration<\/strong><\/td>7-14 working days<\/td><\/tr><\/table><\/details>
Test specifications<\/summary>
Symptom complex<\/strong><\/td>nephrological<\/td><\/tr>
Inheritance<\/strong><\/td>X-chromosomal recessive<\/td><\/tr>
Age of onset<\/strong><\/td>6 months- 2 years <\/td><\/tr>
Causality<\/strong><\/td>causally<\/td><\/tr>
Gene<\/strong><\/td>COL4A5<\/td><\/tr>
Mutation<\/strong><\/td>G-T<\/td><\/tr>
Literature<\/strong><\/td>OMIA:001112-9615<\/a><\/td><\/tr><\/table><\/details><\/div>
Order now ...<\/a><\/strong><\/div><\/div><\/div>
<\/div><\/div>
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