Babesiosis (also known as “canine malaria” or piroplasmosis) is a disease caused by unicellular parasites (babesia) that dogs can get from the bite of infected ticks and is increasingly occurring in Germany. It is mainly transmitted by the meadow tick and the brown dog tick, and more rarely by blood transfusions. If the parasites enter the dog’s bloodstream, they penetrate the red blood cells and multiply there. This destroys the red blood cells, which leads to anemia.

The symptoms usually appear within about 2-3 weeks after the tick bite and are often relatively unspecific. These include severe fatigue, fever, loss of appetite, weight loss, pale mucous membranes and jaundice. A dark red to brown discoloration of the urine can also occur, which is caused by the excretion of blood pigments (haemoglobinuria). If left untreated, the disease can lead to consequential damage to various organs, such as respiratory distress or kidney failure. The nervous system can also be affected, which can manifest itself in seizures, paralysis or movement disorders. Without treatment, babesiosis is often fatal. Early diagnosis and treatment are therefore very important.

As the pathogens are not transmitted directly with the tick bite, but enter the body with a time delay via the tick’s saliva, rapid removal of the tick and suitable tick protection can reduce the risk of babesiosis. A veterinarian should be contacted immediately in case of suspicion.

On our website https://vbd.laboklin.com you will find useful information on babesiosis and other vector-borne infectious diseases (transmitted by mosquitoes or ticks, for example).

Primary hyperparathyroidism (PHPT) is a hereditary disease in which the regulation of calcium levels in the body is disturbed. Possible consequences are an increasing weakening of the bones, kidney problems and even kidney failure as well as other metabolic disorders.

A variant in the SIRT6 gene was found in the Wolfspitz/Keeshond that is associated with the disease. This is inherited in an autosomal dominant manner. The late onset of the disease is particularly challenging for breeders, as the symptoms of PHPT usually only become apparent after the age of 8 and therefore often at a time when the dogs have already been used for breeding. The genetic test enables early identification of affected animals and supports breeders and owners in responsible breeding selection and prevention.

The genetic test for Adult Onset Neuropathy (AON) is now available again! The test is carried out by a partner laboratory and is offered for the English Cocker Spaniel and Field Spaniel breeds.

AON is a hereditary disease whose symptoms are similar to those of degenerative myelopathy (DM). The first symptoms typically appear at the age of 7.5 to 9 years and are characterized by weakness of the hind legs, resulting in an uncoordinated gait and a wide-legged stance. As the disease progresses, the weakness spreads to the front legs and can eventually lead to difficulty swallowing.

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease in which there is an abnormal thickening of the left ventricle. As this ventricle is responsible for the blood supply to the entire body, HCM can significantly impair the heart’s pumping capacity. This can result in a reduced oxygen supply to the organs.

The disease can have serious consequences, including cardiac arrhythmia, abnormal blood clotting (risk of thrombosis) and heart failure. The clinical symptoms are highly variable and range from reduced exercise tolerance and breathing difficulties to fainting or collapse.

A genetic variant in the TNNI3 gene associated with HCM has been identified in a family of Golden Retrievers. The disease is believed to be inherited in an autosomal recessive manner and, in the worst case, can lead to sudden cardiac death.

Cerebellar abiotrophy (CA) is a hereditary neurological disorder that causes changes in the cerebellum, which is particularly responsible for movement coordination and balance.

Two genetic risk markers associated with CA have been identified in the Australian Kelpie. Clinical manifestations of the disease include pronounced ataxia, head tremor, a wide-legged stance of the hind limbs and a conspicuous gait pattern in which the legs are raised excessively when walking.

One variant affects the LINGO3 gene and is inherited in an autosomal recessive manner with incomplete penetrance. The first symptoms of this variant can appear as early as 4 to 10 weeks of age, although the severity of the symptoms can vary greatly. The second variant in the VPM1 gene shows a later onset of the disease (from about 4-6 months or older) and follows an autosomal recessive inheritance with complete penetrance.
Genetic testing makes it possible to identify carrier animals at an early stage and make well-founded breeding decisions.

Hypothyroidism (underactive thyroid) is one of the most common hormonal diseases in dogs. The thyroid gland produces too few hormones (especially T4), which are important for the entire metabolism. Typical signs are weight gain despite a normal amount of food, tiredness and reduced playfulness, skin and coat problems, increased sensitivity to cold and sometimes changes in behavior.

As these symptoms can also occur in many other diseases, a measurement of thyroid hormones alone (especially T4 and TSH) is often not sufficient for a reliable diagnosis. A low T4 level in the blood does not automatically mean hypothyroidism – other non-thyroidal illnesses (NTI) or certain medications can also lower T4. In addition, various interfering factors can distort the measurements.

In order to gain more clarity in unclear cases – such as suspected hypothyroidism with low T4 but unchanged TSH – additional tests are now available at Laboklin. The determination of the thyroid hormone rT3 (reverse T3) provides additional information as to whether an altered hormone status is more consistent with a genuine hypothyroidism or can be explained by another underlying disease (NTI). In addition, thyroid hormones can be determined using a particularly precise mass spectrometric measurement method known as LC-MS/MS. This technique is less susceptible to interference and gives a very reliable picture of the actual hormone concentrations.

Based on the clinical findings of your veterinarian, these modern analyses help to avoid unnecessary or too late thyroid therapy and thus to find the best possible, individually suitable treatment for your dog.

If you have any questions, please contact your veterinary practice or veterinary clinic – they will be happy to help you.

Glycogen storage diseases (GSDs) are hereditary metabolic disorders in which too much glycogen is stored in various tissues due to faulty enzymes. A genetic variant in the RBCK1 gene was discovered in the Basset Hound, which leads to the formation of so-called polyglucosan storage bodies and can cause serious health problems. Affected dogs often initially show chronic vomiting and diarrhea, usually from around 8 to 12 months of age. Later on, progressive muscle weakness, exercise intolerance and serious heart problems with heart failure and even sudden cardiac death can occur.

As the disease progresses gradually and often causes only minimal changes in blood values at the beginning, genetic testing can provide valuable information for the diagnosis. In addition, carrier animals can be identified at an early stage using the genetic test, which is of great importance for responsible breeding planning.

The ridge – the distinctive ridge running against the direction of the coat – is one of the characteristic features of the Rhodesian Ridgeback breed. The appearance of the Ridge is clearly defined by the respective breed standards.

The development of the ridge is caused by a genetic variant on chromosome 18. This is a duplication of an approx. 100 kb long DNA section. The variant follows an autosomal dominant inheritance with incomplete penetrance: in heterozygous dogs with the R/r genotype, around 95% carry a ridge, while in around 5% of dogs the dominant R allele is silenced, meaning that these dogs do not have a ridge.

The genetic test can be used to determine whether the ridge gene is heterozygous (R/r) or homozygous (R/R). The genotypes of the mating partners can be used to predict whether puppies without a ridge can be expected in the offspring.

Our tip: We also offer a new practical Ridge + Dermoidsinus (DS) combination package!

Laboklin’s laboratory results are sent exclusively as PDF files, which are digitally signed and protected against editing. This ensures that the content cannot be changed unnoticed after it has been created. The digital signature confirms the authenticity of the document and proves that it actually originates from Laboklin.

These security measures meet high technical standards and offer reliable protection against manipulation. So you can be sure: When you receive a signed PDF, it has been transmitted unchanged and truthfully.

Despite these high security precautions, fraud can unfortunately never be completely ruled out. We therefore recommend that you only accept findings from trustworthy sources and, if in doubt, contact Laboklin directly. Especially when it comes to important decisions on health care, mating or the purchase of an animal, it is crucial that you can rely on the accuracy and authenticity of the findings.

For data protection reasons, we are not permitted to provide information about the findings of other customers or clients. However, we can confirm the authenticity of an existing finding if there is reasonable doubt.

With these measures, we want to offer you the greatest possible security and transparency – so that you can rely on the accuracy of the results.