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Hyperuricosuria and Hyperuricemia (HUU, SLC)

Disease

Hyperuricosuria and Hyperuricemia cause congenitally changes in the purine metabolism. Naturally, dogs excrete Allantoin as an end-product. Dogs with a homozygous mutation in the SLC2A9-gene excrete less Allantoin and at the same time more uric acid (Hyperuricosuria). Equally, uric acid concentration in plasma increases 2-4 times compared to healthy dogs (Hyperuricemia).
Due to being less water-soluble than Allantoin, higher concentrations of uric acid in urine could lead to the formation of crystals, which build vesical calculus and have to be removed by surgery. Preventative, affected dogs should get a low purine diet. Additionally, adequate hydration is vital.

Breed

All breed

Trait of inheritance

autosomal-recessive

Test duration

3-5 days after arrival of the sample in the lab

Material

The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.

Testing procedure

Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.

Questiones?

Please contact our molecular biology team for further questions.

LABOKLIN GmbH und Co.KG
Steubenstraße 4
D-97688 Bad Kissingen

Tel. 0971 /72020 oder Fax: 0971 / 7202995
Email: labogen""laboklin.de

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