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Startle Disease (SD)BreedIrish Wolfhound The DiseaseStartle disease or Hyperekplexia in Irish Wolfhounds is an inherited brain disorder. The first symptoms appear approximately 5-7 days after birth. Affected dogs show extensor rigidity and tremor evoked by handling. Symptoms may cease when dogs are relaxed or sleeping. Puppies are unable to stand and show a rigid extended posture in all four limbs. Additionally, cyanosis appear while suckling. Affected puppies to date have been euthanised to to poor quality of life. Trait of InheritanceThe mutation responsible for this disease - a deletion in the gene for the glycine transporter GlyT2 – has been identified via PCR testing. This test has very high accuracy and can be performed at any age of the dog. The method is suitable for distinguishing between homozygous affected dogs (SD/SD), heterozygous carrier dogs (N/SD) and non-carrier dogs (homozygous clear N/N). This test provides essential information for the dog breeder enabling him/her to make responsible decisions concerning the breeding of dogs in order to limit the spread of this debilitating disease. DescriptionThe mutation responsible for Startle Disease can now be identified using our DNA test. The test can be performed on dogs of any age and even puppies can be tested. The DNA test differentiates between clear and affected dogs, but also identifies healthy carrier dogs. This is of crucial importance for dog breeders. To achieve a maximum reliability of the test result, we perform the DNA test on each submitted sample in two independent test runs. Sample Material1 ml of EDTA blood or a buccal swab. MethodPCR DurationUsually you will receive the test result 3-5 working days after receival of your sample For further information please contactDr. Petra Kühnlein or Dr. Ines Langbein-Detsch |
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