Genetic testing for JEB 

Breed

German Pointer

JEB - The Disease

JEB (Junctional Epidermolysis bullosa) is a blistering disorder of the skin and mucous membranes in which tissue separation occurs within the lamina lucida of the basement membrane zone at the dermal-epidermal junction. Affected dogs show erosion and encrustation in the field of the balls, knees, elbows, ankle joints, carpal bones, hips, lips and tongue.

JEB - The Trait of Inheritance

JEB in German Pointers is an inherited autosomal recessive trait. This means that a dog can be clear (homozygous normal), affected, or a carrier (heterozygous). The carriers can spread the diseased gene in the population. Therefore, reliable information on non-affected dogs is the key to controlling this disease.

The mutation-based gene test and its advantages

The genetic test detects a SNP mutation that is inherited together with the responsible mutation. This method provides a very high accuracy test and can be done at any age. It offers the possibility to distinguish not only between affected and clear dogs, but also to identify clinically healthy carriers. This is an essential information for controlling the disease in the breed, as carriers are able to spread the disease in the population, but can not be identified by means of common laboratory diagnostic.
The DNA test does not provide informations about onset of clinical signs and the severity of disease symptoms. 

Method

PCR

Requirements

The tests are performed out of EDTA whole blood (0.5 ml) or cheek swabs.

Duration

Testing is performed a few times per week at LABOKLIN. The results are due about one week after arrival of the sample in our laboratory.

For further information please contact

Dr. Petra Kühnlein or Dr. Ines Langbein-Detsch
LABOKLIN GmbH und Co.KG
Steubenstraße 4
D-97688 Bad Kissingen /german

Phone: +49-971-72020 /72020 or Fax: +49-971 / 7202995
Email: labogenlaboklin.de

*) buccal swabs are available upon request at labogenlaboklin.de